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Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.
Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart.
In collaboration with Marianne Grunberg-Manago, Saul Korey and Severo Ochoa he investigated the Mg2+- or Mn2+-dependent formation of acetyl-CoA from acetate and ATP catalyzed by acetate kinase, an essential reaction for priming the tricarboxylate cycle,
With Edward O'Connell, Rose investigated the mechanisms of the reaction catalyzed by phosphoglucose isomerase and, with Sidney Rieder, of triose phosphate isomerase
With Jessie Warms, he studied the mechanism of hexokinase of sarcoma tumor, finding that it was located in the mitochondria of liver and brain, and bound in accord with a Mg2+-dependent equilibrium.
He had a general interest in the role of magnesium in cells, and studied it on the basis of the equilibrium of the reaction catalyzed by adenylate kinase, a complicated question, because numerous complexes of Mg2+, H+ and K+ with ATP, ADP and AMP need to be taken into account.
Starting from Ogston's theory, Rose was concerned with the stereochemistry of enzyme-catalysed reactions, investigating various enzymes, and later glutamine synthetase. This was the topic of a review article written with Kenneth Hanson.
Published work
When Irwin Rose started on his prizewinning work on ubiquitin he was already very distinguished as an enzymologist.
Classical enzymology
Only a selection of Rose's very extensive work in this field is mentioned here.
(2025). 9780121818012 ISBN 9780121818012 describing the purification of the enzyme and measuring the equilibrium constant of the reaction.
Ubiquitin
After its discovery by Gideon Goldstein and colleagues in 1975, ubiquitin was extensively studied by Rose, with Avram Hershko, Aaron Ciechanover, A. L. Haas and H. Heller, one of many papers on the subject.
Awards and honors
Rose was awarded the Nobel prize in 2004.
Personal life
Rose was married to Zelda Budenstein and had four children. He died on June 2, 2015, at Deerfield, Massachusetts. His widow died in 2016.
See also
External links
Categories: 1926 Births, 2015 Deaths, American Biologists, American Nobel Laureates, Jewish American Scientists, Jewish Nobel Laureates, Members Of The United States National Academy Of Sciences, Nobel Laureates In Chemistry, People From Spokane, Washington, University Of California, Irvine Faculty, University Of Chicago Alumni, United States Navy Personnel Of World War Ii, Fox Chase Cancer Center People
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